Acinetobacter baumannii Infections

• Ubiquitous pathogen
  
• Causes bacteremia, endocarditis, pneumonias, wound infection, urine tract infections and meningitis
  
• Aerobic gram negative bacilli, oxidase negative, catalse positive
  
• MDR resistant A. baumanii is defined as resistance to carbapenem or to 3 different class of antibiotics.
  
• Therapeutic options:
  
  • Sulbactam
    
  • Carbapenem: still drug of choices
    
  • Colistin
    
  • Tigecycline
    
  • Intra-thecal Amikacin for meningitis
    
  • Consider aersolozied colistin for VAP
    
  • Consider combination with Rifampin